Results Oxidation process was investigated in order to model the degradation of cetirizine in PEG-containing formulation. The reaction mixture was purified, and the isolated material was analyzed by 1H NMR. Additionally, pure cetirizine was subjected to selective oxidization by hydrogen peroxide and sodium percarbonate. Methods Cetirizine, formulated in PEG-containing matrix, was subjected to forced degradation conditions in the pH range from 3 to 10, and the product was analyzed by HPLC and LC-MS/MS. Received: / Accepted: 24 November 2009 / Published online: 31 March 2010 # Springer Science+Business Media, LLC 2010ĪBSTRACT Purpose The goal of the study was to isolate and analyze a cetirizine degradation product, formed within a PEG-containing formulation and to elucidate the mechanism of oxidation of cetirizine. Isolation and Characterization of Cetirizine Degradation Product: Mechanism of Cetirizine Oxidation Tatyana Dyakonov & April Muir & Hassen Nasri & Dana Toops & Aqeel Fatmi
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